Improving the design of natural product libraries for drug discovery
An LCMS-guided bioanalytical approach for rational natural product library design and optimization
This study is looking at how to improve the selection of natural ingredients for new medicines, using a special technique to find the best options, which could help create better treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | San Diego State University NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project ID | NIH-10862659 on NIH RePORTER |
What this research studies
This research focuses on enhancing the design of natural product libraries, which are crucial for drug discovery. By utilizing a technique called liquid chromatography-tandem mass spectrometry (LC-MS/MS), the team aims to identify the most effective natural extracts to include in these libraries. This method allows for a more efficient selection process, potentially reducing the number of extracts needed while maximizing chemical diversity. Patients may benefit from this research as it could lead to the development of new and more effective medications derived from natural products.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could be treated by new natural product-derived medications.
Not a fit: Patients who do not have conditions that can be addressed by natural products may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the discovery of new drugs that are more effective and have fewer side effects.
How similar studies have performed: Previous research has shown promise in using LC-MS/MS for optimizing natural product libraries, indicating that this approach could be effective.
Where this research is happening
San Diego, United States
- San Diego State University — San Diego, United States (Active)
Researchers
- Principal investigator: Mccall, Laura-Isobel — San Diego State University
- Study coordinator: Mccall, Laura-Isobel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.