Improving the delivery of genetic material using advanced lipid nanoparticles
Official title: Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery
Funded at Osem Fluidics INC · NIH-11269095 · Data updated 2026-11-12
This study is working on making tiny particles that help deliver important genetic materials, like mRNA, into cells more effectively, using special techniques to create better designs for these particles, which could improve treatments for various health conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Osem Fluidics INC NIH-funded |
| Lab location | 1 site (Alhambra, United States) |
| Project start | January 1, 2025 |
| Project end | June 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $43,000 |
| NIH project number | 3R43GM157920-01S1 |
| Project ID | NIH-11269095 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who may benefit from nucleic acid-based therapies, particularly those with conditions treatable by mRNA or siRNA.
✕Less likely to help
Patients who do not require nucleic acid therapies or those with conditions unrelated to genetic material delivery may not benefit from this research.
What this research studies
This research focuses on enhancing the manufacturing process of lipid nanoparticles (LNPs) that are crucial for delivering nucleic acids, such as mRNA and siRNA, effectively. By utilizing advanced microfluidic techniques, the project aims to design and test three-dimensional channel architectures that can precisely control the properties of LNPs. This approach seeks to improve the efficiency of these nanoparticles in delivering genetic material into cells, which is vital for various therapeutic applications. The research will involve both simulation and experimental studies to assess how different LNP structures impact their performance in laboratory settings.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases that require nucleic acid therapies, such as certain cancers and genetic disorders.
How similar studies have gone: Other research has shown promise in using microfluidic techniques for nanoparticle production, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
Osem Fluidics INC
Alhambra, United States Active
Researchers
- Principal investigator: Feng, Po-Lun — Osem Fluidics INC
- Study coordinator: Feng, Po-Lun
Related research
Other NIH-funded projects on the same topics.
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Improving the delivery of genetic material using advanced 3D-printed lipid nanoparticles
This study is working on a new way to make tiny delivery systems called lipid nanoparticles that can carry important genetic materials like mRNA into cells more effectively, using special 3D printing techniques, to help improve treatments for various health conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.