Improving the delivery of genetic material using advanced lipid nanoparticles
Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery
This study is working on making tiny particles that help deliver important genetic materials, like mRNA, into cells more effectively, using special techniques to create better designs for these particles, which could improve treatments for various health conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Osem Fluidics INC NIH-funded |
| Lab location | 1 site (Alhambra, United States) |
| Project ID | NIH-11269095 on NIH RePORTER |
What this research studies
This research focuses on enhancing the manufacturing process of lipid nanoparticles (LNPs) that are crucial for delivering nucleic acids, such as mRNA and siRNA, effectively. By utilizing advanced microfluidic techniques, the project aims to design and test three-dimensional channel architectures that can precisely control the properties of LNPs. This approach seeks to improve the efficiency of these nanoparticles in delivering genetic material into cells, which is vital for various therapeutic applications. The research will involve both simulation and experimental studies to assess how different LNP structures impact their performance in laboratory settings.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who may benefit from nucleic acid-based therapies, particularly those with conditions treatable by mRNA or siRNA.
Not a fit: Patients who do not require nucleic acid therapies or those with conditions unrelated to genetic material delivery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases that require nucleic acid therapies, such as certain cancers and genetic disorders.
How similar studies have performed: Other research has shown promise in using microfluidic techniques for nanoparticle production, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Alhambra, United States
- Osem Fluidics INC — Alhambra, United States (Active)
Researchers
- Principal investigator: Feng, Po-Lun — Osem Fluidics INC
- Study coordinator: Feng, Po-Lun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.