Improving the delivery of genetic material using advanced 3D-printed lipid nanoparticles
Official title: Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery
Funded at Osem Fluidics INC · NIH-11070059 · Data updated 2026-11-12
This study is working on a new way to make tiny delivery systems called lipid nanoparticles that can carry important genetic materials like mRNA into cells more effectively, using special 3D printing techniques, to help improve treatments for various health conditions.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Osem Fluidics INC NIH-funded |
| Lab location | 1 site (Alhambra, United States) |
| Project start | January 1, 2025 |
| Project end | June 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $306,873 |
| NIH project number | 1R43GM157920-01 |
| Project ID | NIH-11070059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who may benefit from advanced nucleic acid therapies, such as those receiving mRNA vaccines or gene therapies.
✕Less likely to help
Patients who are not candidates for nucleic acid-based therapies or those with conditions unrelated to the delivery of genetic material may not receive benefits from this research.
What this research studies
This research focuses on enhancing the delivery of nucleic acids, such as mRNA and siRNA, using lipid nanoparticles (LNPs) that are manufactured with advanced 3D printing techniques. By developing specialized microfluidic systems, the project aims to create precise channel architectures that can control the structure and properties of LNPs, ultimately improving their effectiveness in delivering genetic material into cells. The research involves designing and testing various 3D channel configurations, analyzing the resulting LNP structures, and evaluating their transfection efficiency through laboratory studies. This innovative approach seeks to address current limitations in LNP manufacturing and enhance their therapeutic potential.
Why it matters
Potential benefit: If successful, this research could lead to more effective and reliable delivery systems for vaccines and gene therapies, improving patient outcomes.
How similar studies have gone: Previous research has shown promise in using lipid nanoparticles for drug delivery, indicating that this approach could build on established successes in the field.
Where this research is happening
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Osem Fluidics INC
Alhambra, United States Active
Researchers
- Principal investigator: Feng, Po-Lun — Osem Fluidics INC
- Study coordinator: Feng, Po-Lun
Related research
Other NIH-funded projects on the same topics.
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Improving the delivery of genetic material using advanced lipid nanoparticles
This study is working on making tiny particles that help deliver important genetic materials, like mRNA, into cells more effectively, using special techniques to create better designs for these particles, which could improve treatments for various health conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.