Improving the delivery and effectiveness of therapeutic nucleic acids
Achieving enhanced cytosolic delivery and greater efficacy of therapeutic nucleic acids using DNA-surfactant conjugates
This study is looking at a new way to help medicines made from DNA get into cells more easily, which could make treatments for different diseases work better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10889964 on NIH RePORTER |
What this research studies
This research focuses on enhancing the delivery of therapeutic nucleic acids (TNAs) to cells, which is crucial for treating various diseases. The approach involves creating DNA-surfactant conjugates that can better penetrate cell membranes and escape endosomal compartments, allowing for more effective gene silencing. By systematically studying the properties of these conjugates, such as their charge and size, the research aims to optimize their ability to deliver therapeutic agents directly to the cytosol of cells. This could lead to improved outcomes in clinical applications of TNAs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with diseases that could benefit from gene silencing therapies, particularly those with conditions currently lacking effective treatments.
Not a fit: Patients who do not have conditions treatable by therapeutic nucleic acids may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diseases that currently have limited options, by improving the efficacy of therapeutic nucleic acids.
How similar studies have performed: Other research has shown promise in enhancing the delivery of therapeutic nucleic acids using various chemical approaches, indicating that this area of study is both relevant and potentially impactful.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Rouge, Jessica L — University of Connecticut Storrs
- Study coordinator: Rouge, Jessica L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.