Improving the creation of heart cells from stem cells
Official title: Enhancing robustness of human pluripotent stem cell differentiation to cardiomyocytes by uncovering on- and off-target differentiation trajectories via single nucleus multi-omics
Funded at University of Wisconsin-Madison · NIH-10899966 · Data updated 2026-11-12
This study is looking at how to better turn special stem cells into heart muscle cells, which is important for helping people with heart disease, and by understanding this process, researchers hope to make treatments more effective and reliable.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $40,844 |
| NIH project number | 1F30HL173988-01 |
| Project ID | NIH-10899966 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or conditions that affect heart function.
✕Less likely to help
Patients with non-cardiac conditions or those who do not have heart disease may not benefit from this research.
What this research studies
This research focuses on enhancing the process of turning human pluripotent stem cells into heart muscle cells, which is crucial for treating heart disease. By using advanced techniques like single nucleus RNA and ATAC sequencing, the researchers aim to understand the different pathways these stem cells take during their transformation. This understanding could help reduce variability in the production of heart cells, making it more reliable for therapies and drug testing. The study seeks to identify the molecular events that lead to successful heart cell differentiation, which could ultimately improve treatment options for patients with heart conditions.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for heart disease by providing a reliable source of heart muscle cells for treatment.
How similar studies have gone: Previous research has shown promise in using stem cells for cardiac applications, but this approach aims to refine and enhance existing methods, making it a novel investigation.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Feeney, Austin K. — University of Wisconsin-Madison
- Study coordinator: Feeney, Austin K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.