Improving the creation of heart cells from stem cells
Enhancing robustness of human pluripotent stem cell differentiation to cardiomyocytes by uncovering on- and off-target differentiation trajectories via single nucleus multi-omics
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10899966
This study is looking at how to better turn special stem cells into heart muscle cells, which is important for helping people with heart disease, and by understanding this process, researchers hope to make treatments more effective and reliable.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10899966 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the process of turning human pluripotent stem cells into heart muscle cells, which is crucial for treating heart disease. By using advanced techniques like single nucleus RNA and ATAC sequencing, the researchers aim to understand the different pathways these stem cells take during their transformation. This understanding could help reduce variability in the production of heart cells, making it more reliable for therapies and drug testing. The study seeks to identify the molecular events that lead to successful heart cell differentiation, which could ultimately improve treatment options for patients with heart conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart disease or conditions that affect heart function.
Not a fit: Patients with non-cardiac conditions or those who do not have heart disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for heart disease by providing a reliable source of heart muscle cells for treatment.
How similar studies have performed: Previous research has shown promise in using stem cells for cardiac applications, but this approach aims to refine and enhance existing methods, making it a novel investigation.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FEENEY, AUSTIN K. — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: FEENEY, AUSTIN K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases, Cardiac Disorders