Improving the consistency of brain imaging data across different research sites
Harmonization of Multi-Site Neuroimaging Data from Complex Study Designs
This study is working to make brain scans from different places more accurate and reliable, which can help doctors better understand and treat conditions like Alzheimer's disease, ultimately leading to better care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11064000 on NIH RePORTER |
What this research studies
This research focuses on enhancing the quality and reliability of neuroimaging data collected from multiple sites, particularly in studies related to brain development and aging. By applying advanced statistical methods, the project aims to correct for variations in imaging results that arise from differences in scanning protocols across locations. This harmonization is crucial for accurately interpreting brain health and disease, especially in conditions like Alzheimer's disease. Patients may benefit from improved diagnostic tools and treatment strategies that arise from more reliable imaging data.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals undergoing neuroimaging for conditions related to aging or cognitive decline, such as Alzheimer's disease.
Not a fit: Patients with neurological conditions that do not involve neuroimaging or those not participating in multi-site studies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better-targeted treatments for neurological conditions.
How similar studies have performed: Previous research has successfully applied statistical harmonization methods in other fields, indicating a promising potential for similar success in neuroimaging.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shinohara, Russell Takeshi — University of Pennsylvania
- Study coordinator: Shinohara, Russell Takeshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.