Improving the body's response to low oxygen levels in pulmonary arterial hypertension
Therapeutic Rescue of a Deficient BMPR2 Hypoxic Response in Pulmonary Arterial Hypertension
['FUNDING_OTHER'] · FLORIDA INTERNATIONAL UNIVERSITY · NIH-10901846
This study is looking at how a gene called BMPR2 helps people with pulmonary arterial hypertension (PAH) deal with low oxygen levels, and it’s exploring new ways to use tiny particles that carry signals between cells to improve treatments and possibly slow down the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA INTERNATIONAL UNIVERSITY (nih funded) |
| Locations | 1 site (MIAMI, UNITED STATES) |
| Trial ID | NIH-10901846 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how a specific gene, BMPR2, affects the body's response to low oxygen levels in patients with pulmonary arterial hypertension (PAH). The project aims to explore new therapeutic strategies using extracellular vesicles, which are tiny particles that can carry important signals between cells. By investigating how these vesicles can be used to enhance the function of BMPR2, the research seeks to develop potential treatments that could reverse disease progression. The study involves advanced techniques such as in vivo surgery and imaging to assess the effectiveness of these therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension, particularly those with a deficiency in the BMPR2 gene.
Not a fit: Patients without pulmonary arterial hypertension or those whose condition is not related to BMPR2 dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve the health and quality of life for patients with pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promise in using extracellular vesicles for therapeutic purposes, indicating that this approach could be a viable strategy for treating PAH.
Where this research is happening
MIAMI, UNITED STATES
- FLORIDA INTERNATIONAL UNIVERSITY — MIAMI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARCIANO, DAVID P — FLORIDA INTERNATIONAL UNIVERSITY
- Study coordinator: MARCIANO, DAVID P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.