Improving the accuracy of AI language models in healthcare

Addressing Factual Inaccuracy and Unfaithful Reasoning of Large Language Models in Biomedicine and Healthcare

NIH-funded research Yale University · NIH-10946218

This study is working to make AI tools used in healthcare more trustworthy, so they give accurate information and help doctors make better decisions, ultimately keeping patients safer and better informed.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10946218 on NIH RePORTER

What this research studies

This research focuses on enhancing the reliability of large language models (LLMs) used in biomedical and healthcare settings. It aims to address issues of factual inaccuracy and unfaithful reasoning in AI-generated responses, which can lead to misinformation and potential misdiagnosis. The project will explore methods for fact-checking and ensuring that AI systems provide evidence-based information, ultimately improving decision-making in healthcare. By refining these AI tools, the research seeks to make them safer and more effective for medical applications.

Who could benefit from this research

Good fit: Ideal candidates for benefiting from this research include patients who rely on AI-assisted tools for medical information and decision-making.

Not a fit: Patients who do not use AI tools or who receive care in settings that do not utilize advanced AI technologies may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more accurate and trustworthy AI tools that assist healthcare professionals in making better-informed decisions.

How similar studies have performed: Other research has shown promise in improving AI accuracy in various fields, suggesting that similar approaches could be effective in healthcare.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.