Improving the ability to monitor brain activity in three dimensions
ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
This study is exploring new ways to watch how electrical signals move in brain cells using special tools, which could help us understand how the brain works and how to better treat brain disorders.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10920480 on NIH RePORTER |
What this research studies
This research focuses on developing advanced techniques to monitor voltage dynamics in neurons using genetically encoded voltage indicators (GEVIs). By utilizing two-photon microscopy, the study aims to enhance the ability to capture fast and deep-tissue voltage changes in the brains of awake mice. The goal is to overcome current limitations in recording from neurons located at different depths, which is crucial for understanding how neurons communicate and process information. This innovative approach could lead to better insights into brain function and disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with neurological conditions that affect brain function.
Not a fit: Patients with conditions unrelated to neuronal activity or those not eligible for animal studies may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve our understanding of brain activity and lead to advancements in treating neurological disorders.
How similar studies have performed: Previous research using genetically encoded voltage indicators and two-photon microscopy has shown promising results, indicating that this approach has potential for success.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: St-Pierre, Francois — Baylor College of Medicine
- Study coordinator: St-Pierre, Francois
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.