Improving the ability to monitor brain activity in three dimensions
Official title: ENABLING SUBMILLISECOND-TIMESCALE TWO-PHOTON RECORDING OF VOLTAGE DYNAMICS IN THREE DIMENSIONS IN VIVO
Funded at Baylor College of Medicine · NIH-10920480 · Data updated 2026-11-12
This study is exploring new ways to watch how electrical signals move in brain cells using special tools, which could help us understand how the brain works and how to better treat brain disorders.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $995,644 |
| NIH project number | 5U01NS133971-02 |
| Project ID | NIH-10920480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals with neurological conditions that affect brain function.
✕Less likely to help
Patients with conditions unrelated to neuronal activity or those not eligible for animal studies may not receive any benefit from this research.
What this research studies
This research focuses on developing advanced techniques to monitor voltage dynamics in neurons using genetically encoded voltage indicators (GEVIs). By utilizing two-photon microscopy, the study aims to enhance the ability to capture fast and deep-tissue voltage changes in the brains of awake mice. The goal is to overcome current limitations in recording from neurons located at different depths, which is crucial for understanding how neurons communicate and process information. This innovative approach could lead to better insights into brain function and disorders.
Why it matters
Potential benefit: If successful, this research could significantly improve our understanding of brain activity and lead to advancements in treating neurological disorders.
How similar studies have gone: Previous research using genetically encoded voltage indicators and two-photon microscopy has shown promising results, indicating that this approach has potential for success.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: St-Pierre, Francois — Baylor College of Medicine
- Study coordinator: St-Pierre, Francois
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.