Improving the ability of the immune system to target HIV-infected cells
Enhancing Susceptibility of HIV Reservoirs to CTL Through a Discovery to Translational Approach
This study is looking at how HIV hides in the body even when people are on treatment, and it aims to find ways to help the immune system better fight off the virus, which could lead to new ways to cure HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11035193 on NIH RePORTER |
What this research studies
This research aims to enhance the immune response against HIV by understanding how the virus persists in the body despite treatment. It investigates the mechanisms that allow HIV-infected cells to evade destruction by the immune system, particularly focusing on the role of cytotoxic T-lymphocytes. By exploring these mechanisms, the research seeks to develop strategies that could make these hidden HIV reservoirs more susceptible to immune attack. This could potentially lead to breakthroughs in curing HIV infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy but have not achieved a complete cure.
Not a fit: Patients who are not living with HIV or those who have advanced AIDS with significant immune system compromise may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a functional cure for HIV, reducing the need for lifelong antiretroviral therapy.
How similar studies have performed: While there have been various approaches to targeting HIV reservoirs, this specific method of enhancing immune response through understanding cell-intrinsic resistance is relatively novel and has not been extensively tested.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Jones, R. Brad — Weill Medical Coll of Cornell Univ
- Study coordinator: Jones, R. Brad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.