Improving tendon-to-bone healing with a new biomaterial implant
Stratified and mechanically-tough biomaterial implant to improve tendon-to-bone enthesis regeneration
This study is testing a new type of implant designed to help heal rotator cuff tears better by using a special material that works like your natural tendon and bone, and it includes stem cells to boost healing during surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Urbana-Champaign NIH-funded |
| Lab location | 1 site (Champaign, United States) |
| Project ID | NIH-10886539 on NIH RePORTER |
What this research studies
This research focuses on enhancing the healing process of rotator cuff tears by developing a specialized biomaterial implant that mimics the natural structure of the tendon-to-bone interface. The approach involves using a stratified biomaterial that combines different mechanical properties to reduce strain and improve the integration of the tendon with the bone. By incorporating mesenchymal stem cells (MSCs) into this biomaterial during surgery, the goal is to promote better regeneration of the damaged area. The study will evaluate how this innovative implant can improve healing outcomes compared to traditional methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from rotator cuff tears who are undergoing surgical repair.
Not a fit: Patients with chronic rotator cuff injuries that are not suitable for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for rotator cuff injuries, reducing the risk of re-injury and improving recovery times.
How similar studies have performed: Previous research has shown promise in using biomaterials for tendon-to-bone healing, indicating that this approach has potential for success.
Where this research is happening
Champaign, United States
- University of Illinois at Urbana-Champaign — Champaign, United States (Active)
Researchers
- Principal investigator: Harley, Brendan a. — University of Illinois at Urbana-Champaign
- Study coordinator: Harley, Brendan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.