Improving tendon healing using stem cell-derived vesicles
Official title: Regulation of Tendon Repair with Stem Cell-Derived Extracellular Vesicles
Funded at Washington University · NIH-10929503 · Data updated 2026-11-12
This study is looking at how tiny particles from special stem cells can help heal tendon injuries better by reducing inflammation and boosting recovery, so if you have a tendon injury, this research could lead to new treatments that might help you heal faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $501,450 |
| NIH project number | 1R56AR082970-01 |
| Project ID | NIH-10929503 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from tendon or ligament injuries who are experiencing prolonged pain and functional limitations.
✕Less likely to help
Patients with chronic tendon injuries that have already undergone extensive surgical interventions may not benefit from this research.
What this research studies
This research investigates how extracellular vesicles from inflammation-primed adipose-derived stem cells can enhance tendon repair. It focuses on identifying specific subpopulations of these vesicles that carry beneficial molecules for healing while reducing inflammation. By sorting these vesicles based on their cargo, the research aims to develop targeted therapies that improve recovery from tendon injuries. Patients with tendon injuries may benefit from this innovative approach to enhance their healing process.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for tendon injuries, reducing pain and improving recovery times for patients.
How similar studies have gone: Previous research has shown promise in using stem cell-derived extracellular vesicles for tissue repair, indicating potential success for this approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Shen, Hua — Washington University
- Study coordinator: Shen, Hua
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.