Improving techniques to study protein interactions in cells
Advancing Proteomics Technologies to Decipher the Ubiquitin-Proteasome System
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA-IRVINE · NIH-10895414
This study is looking at how proteins work together in our cells, which is important for keeping us healthy, and it aims to find out how problems with these interactions can lead to diseases like cancer and brain disorders, so we can better understand these conditions and help create new treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA-IRVINE (nih funded) |
| Locations | 1 site (IRVINE, UNITED STATES) |
| Trial ID | NIH-10895414 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how proteins interact within cells, which is crucial for many biological functions. By using advanced techniques like cross-linking mass spectrometry, the researchers aim to capture and analyze these interactions in their natural environments. This approach will help identify how disruptions in these interactions can lead to diseases, including various cancers and neurodegenerative disorders. Ultimately, the goal is to enhance our understanding of cellular processes and support the development of new therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or degenerative neurologic disorders linked to protein interaction abnormalities.
Not a fit: Patients with conditions unrelated to protein interactions or those not affected by cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for diseases caused by faulty protein interactions.
How similar studies have performed: Previous research using similar proteomics techniques has shown promise in understanding protein interactions and their implications in various diseases.
Where this research is happening
IRVINE, UNITED STATES
- UNIVERSITY OF CALIFORNIA-IRVINE — IRVINE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, LAN — UNIVERSITY OF CALIFORNIA-IRVINE
- Study coordinator: HUANG, LAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers