Improving techniques to analyze proteins in biological samples
Official title: Developing proteomics pipelines to improve depth, throughput, and accuracy
Funded at Harvard Medical School · NIH-11011181 · Data updated 2026-11-12
This study is working on improving a technique that helps scientists look at proteins in samples from the body, which could lead to better ways to understand diseases and create more effective tests and treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 16, 2025 |
| Project end | January 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $453,750 |
| NIH project number | 1R35GM156406-01 |
| Project ID | NIH-11011181 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions that involve protein abnormalities or require advanced diagnostic techniques.
✕Less likely to help
Patients with conditions unrelated to protein analysis or those who do not require advanced diagnostic methods may not receive benefit from this research.
What this research studies
This research focuses on enhancing mass spectrometry-based proteomics, a method used to study proteins in biological samples. The project aims to overcome current limitations in sample preparation and data acquisition, which affect the accuracy and efficiency of protein analysis. By developing new technologies and optimizing existing processes, the research seeks to enable deeper and more comprehensive profiling of proteins and their modifications. Patients may benefit from advancements in understanding diseases at the molecular level, leading to better diagnostics and treatments.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and efficient methods for diagnosing and treating various diseases by providing deeper insights into protein functions and modifications.
How similar studies have gone: Other research in mass spectrometry-based proteomics has shown significant advancements, indicating that this approach has the potential for success.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Paulo, Joao a — Harvard Medical School
- Study coordinator: Paulo, Joao a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.