Improving techniques for studying protein structures using X-ray crystallography
Official title: Macromolecular Crystallography Operations Core
Funded at Uchicago Argonne, LLC · NIH-10929364 · Data updated 2026-11-12
This study is working on making it easier for scientists to look at protein structures using special X-ray techniques, so they can better understand how proteins affect our health and diseases.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Uchicago Argonne, LLC NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 30, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,927,045 |
| NIH project number | 5P30GM138396-05 |
| Project ID | NIH-10929364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or cancers.
✕Less likely to help
Patients with conditions that do not involve protein structures or those who are not involved in research settings may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the capabilities of macromolecular crystallography to better analyze protein structures. It aims to create a user-friendly interface for both on-site and remote researchers, allowing for efficient sample screening and data collection. The project will upgrade existing beamline optics and software to improve the quality and accessibility of X-ray diffraction experiments, which are crucial for understanding complex biological processes. By implementing these advancements, the research will facilitate more effective studies of proteins that are vital for health and disease.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in our understanding of protein structures, potentially aiding in the development of new therapies for various diseases.
How similar studies have gone: Previous research in macromolecular crystallography has shown success in improving our understanding of protein structures, indicating that this approach has the potential for significant advancements.
Where this research is happening
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Uchicago Argonne, LLC
Chicago, United States Active
Researchers
- Principal investigator: Fischetti, Robert F. — Uchicago Argonne, LLC
- Study coordinator: Fischetti, Robert F.
Related research
Other NIH-funded projects on the same topics.
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Training users on advanced crystallography technologies
This study is all about helping scientists learn how to use new tools and techniques to better understand the structures of large molecules, with friendly training sessions and hands-on workshops to boost their skills.
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Improving resources for macromolecular crystallography to solve biomedical problems
This study is all about making a special lab better for scientists who study the tiny structures of important biological molecules, so they can do their experiments more easily and effectively.
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Access to advanced tools for determining 3D structures of biological molecules
This study is all about using advanced technology to help scientists figure out the 3D shapes of important biological molecules, which can lead to new treatments and therapies for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.