Improving T cell therapy for multiple myeloma treatment
Official title: preclinical optimization of BCMA directed T cell therapy
Funded at Mayo Clinic Arizona · NIH-10931634 · Data updated 2026-11-12
This study is looking at ways to make T cell therapy better for people with multiple myeloma by understanding how the cancer affects nearby immune cells and testing different treatment combinations to help the immune system fight the cancer more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $590,784 |
| NIH project number | 5R01CA272426-02 |
| Project ID | NIH-10931634 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with multiple myeloma who have not responded adequately to existing therapies.
✕Less likely to help
Patients with early-stage multiple myeloma or those who have not yet undergone treatment may not benefit from this research.
What this research studies
This research focuses on enhancing T cell therapy specifically targeting BCMA in patients with multiple myeloma. It aims to understand how the tumor affects surrounding immune cells and how different therapies influence this interaction. By using a unique mouse model that closely mimics human immune responses, the researchers will explore combination therapies that could improve T cell function and effectiveness against the tumor. The goal is to develop more effective treatment strategies that could lead to better patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for multiple myeloma, potentially improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promising results with similar immunotherapy approaches, indicating potential for success in this area.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Chesi, Marta — Mayo Clinic Arizona
- Study coordinator: Chesi, Marta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.