Improving T cell responses to cancer treatment
Rewiring T cell exhaustion with immune checkpoint blockade therapy
This study is looking at ways to make cancer treatments work better by helping your immune system's T cells, which are important for fighting tumors, stay strong and effective, especially for those receiving PD-1 therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10982379 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of immune checkpoint blockade therapy, specifically targeting PD-1, by promoting the development and maintenance of CD8+ T cells that are crucial for fighting tumors. The approach focuses on understanding the role of specific T cell subsets, including stem-cell like and precursor exhausted T cells, in improving patient responses to treatment. By exploring the function of PSGL-1 as a potential target, the research aims to overcome resistance to immunotherapy and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients undergoing PD-1 immune checkpoint blockade therapy.
Not a fit: Patients who are not receiving PD-1 therapy or those with conditions unrelated to T cell exhaustion may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that enhance patient responses and prolong survival.
How similar studies have performed: Previous research has shown promising results in enhancing T cell responses through similar immunotherapy approaches, indicating potential for success in this area.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Bradley, Linda Mac Pherson — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Bradley, Linda Mac Pherson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.