Improving T cell responses to cancer treatment
Official title: Rewiring T cell exhaustion with immune checkpoint blockade therapy
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10982379 · Data updated 2026-11-12
This study is looking at ways to make cancer treatments work better by helping your immune system's T cells, which are important for fighting tumors, stay strong and effective, especially for those receiving PD-1 therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | August 7, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $674,996 |
| NIH project number | 1R01CA287114-01A1 |
| Project ID | NIH-10982379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients undergoing PD-1 immune checkpoint blockade therapy.
✕Less likely to help
Patients who are not receiving PD-1 therapy or those with conditions unrelated to T cell exhaustion may not benefit from this research.
What this research studies
This research investigates how to enhance the effectiveness of immune checkpoint blockade therapy, specifically targeting PD-1, by promoting the development and maintenance of CD8+ T cells that are crucial for fighting tumors. The approach focuses on understanding the role of specific T cell subsets, including stem-cell like and precursor exhausted T cells, in improving patient responses to treatment. By exploring the function of PSGL-1 as a potential target, the research aims to overcome resistance to immunotherapy and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that enhance patient responses and prolong survival.
How similar studies have gone: Previous research has shown promising results in enhancing T cell responses through similar immunotherapy approaches, indicating potential for success in this area.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Bradley, Linda Mac Pherson — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Bradley, Linda Mac Pherson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.