Improving T cell recovery after blood stem cell transplants
Official title: Promoting T cell reconstitution after hematopoietic cell transplantation
Funded at Fred Hutchinson Cancer Center · NIH-11001837 · Data updated 2026-11-12
This study is looking at ways to help your immune system recover better after a stem cell transplant by finding ways to repair the thymus, the organ that makes T cells, which are important for fighting infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,075,992 |
| NIH project number | 5R35HL171556-02 |
| Project ID | NIH-11001837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who are undergoing or have recently undergone hematopoietic cell transplantation.
✕Less likely to help
Patients who have not received HSCT or those with conditions unrelated to T cell recovery may not benefit from this research.
What this research studies
This research focuses on enhancing the recovery of T cells, which are crucial for immune function, following hematopoietic cell transplantation (HSCT). It investigates the thymus, the organ responsible for T cell generation, and how it can be repaired after damage caused by cancer treatments. The study aims to identify therapies that stimulate the natural regenerative processes of the thymus, particularly through the roles of specific signaling molecules and cell death pathways. By understanding these mechanisms, the research seeks to improve patient outcomes post-transplant.
Why it matters
Potential benefit: If successful, this research could lead to improved immune recovery for patients undergoing blood stem cell transplants, reducing the risk of infections and complications.
How similar studies have gone: Previous research has shown promise in enhancing thymic regeneration and T cell recovery, indicating that this approach has potential for success.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Dudakov, Jarrod — Fred Hutchinson Cancer Center
- Study coordinator: Dudakov, Jarrod
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.