Improving T cell function to enhance cancer treatment
EPIGENETIC REPROGRAMMING OF T CELL EXHAUSTION TO ENHANCE TUMOR IMMUNOTHERAPY
This study is looking at ways to make T cell therapies work better for people with acute myeloid leukemia (AML) by figuring out how to help tired T cells fight the cancer more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10990418 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of T cell therapies for patients with acute myeloid leukemia (AML) by addressing T cell exhaustion. The team is exploring the role of specific molecules in the tumor environment that may hinder T cell activity and how modifying these can improve T cell responses. By understanding the epigenetic changes that occur in T cells within suppressive environments, the researchers aim to develop strategies that could lead to better outcomes for patients receiving CAR T cell therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older diagnosed with acute myeloid leukemia who are undergoing or considering CAR T cell therapy.
Not a fit: Patients with other types of leukemia or those who are not eligible for CAR T cell therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in enhancing T cell responses through similar immunotherapeutic approaches, indicating potential for success in this area.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Youngblood, Benjamin Alan — St. Jude Children's Research Hospital
- Study coordinator: Youngblood, Benjamin Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.