Improving symptom management and physical activity for stem cell transplant patients
Official title: Randomized Controlled Trial of a Hybrid-Delivered Cognitive Behavioral Symptom Management and Activity Coaching Intervention for Stem Cell Transplant Patients
Funded at Duke University · NIH-10937615 · Data updated 2026-11-12
This study is testing a new program called Step Up to help people who have had a stem cell transplant feel better and get moving again by combining in-person support and mobile health tools, so they can better manage symptoms like fatigue and pain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $561,734 |
| NIH project number | 1R01CA291888-01 |
| Project ID | NIH-10937615 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently undergone hematopoietic stem cell transplant and are experiencing symptoms that hinder their physical activity.
✕Less likely to help
Patients who are not eligible for stem cell transplant or those who do not experience significant symptoms affecting their physical activity may not benefit from this research.
What this research studies
This research focuses on helping patients who have undergone hematopoietic stem cell transplant (HCT) manage their symptoms and increase their physical activity through a hybrid approach that combines in-person sessions and mobile health technology. The intervention, called Step Up, includes cognitive behavioral coping skills training and activity coaching led by occupational therapists. Patients will receive both in-person and video sessions to support their recovery and enhance their ability to cope with fatigue, pain, and distress. The study aims to determine the effectiveness of this intervention compared to standard care.
Why it matters
Potential benefit: If successful, this research could significantly improve the quality of life for stem cell transplant patients by enhancing their physical activity and reducing debilitating symptoms.
How similar studies have gone: Previous studies have shown promising results with similar hybrid interventions, indicating potential for success in this approach.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Kelleher, Sarah — Duke University
- Study coordinator: Kelleher, Sarah
Related research
Other NIH-funded projects on the same topics.
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Step Up: A blended coaching program to help stem cell transplant patients be active
A walking-and-skills program using coaching and a mobile app helps stem cell transplant patients cope with symptoms so they can be more active.
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SHIFT: A digital tool to help stem cell transplant survivors feel better sexually and emotionally
A new digital app called SHIFT will be tested to help hematopoietic stem cell transplant survivors improve sexual health, quality of life, and psychological well-being.
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Hybrid app plus coaching to help stem cell transplant patients manage symptoms and stay active
This program uses a brief in-person visit, video coaching, and a smartphone app to help people who had a hematopoietic stem cell transplant manage fatigue, pain, and distress so they can safely increase daily activity.
-
SHIFT: A Digital App for Stem Cell Transplant Survivors
This project is testing a new digital app called SHIFT to help people who have had a stem cell transplant improve their sexual health, quality of life, and overall well-being.
-
A digital app to improve sexual health for stem cell transplant survivors
This study is testing a new app called SHIFT to help people who have had stem cell transplants improve their sexual health and overall well-being, making it easier for them to manage common issues like sexual dysfunction.
-
Cognitive behavioral therapy and trazodone for insomnia phenotypes with high blood pressure
A clinical study tests how CBT-I and the sleep drug trazodone work for adults with insomnia and high blood pressure, focusing on a specific sleep duration pattern.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.