Improving survival rates in children with cardiac arrest and pulmonary hypertension
Pulmonary Hypertension-Associated Pediatric Cardiac Arrest
This study is looking at ways to help kids with pulmonary hypertension who have a cardiac arrest by using special CPR techniques and a medicine called inhaled nitric oxide to improve their chances of survival.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10798305 on NIH RePORTER |
What this research studies
This research focuses on enhancing the survival outcomes of children who experience cardiac arrest, particularly those with pulmonary hypertension. By utilizing physiology-directed cardiopulmonary resuscitation (CPR) techniques, the study aims to personalize resuscitation efforts based on the specific physiological challenges faced by these patients. The approach includes a randomized trial using inhaled nitric oxide, a pulmonary vasodilator, to improve blood flow and pressure during CPR. The goal is to gather high-quality data that could lead to better treatment protocols for pediatric cardiac arrest.
Who could benefit from this research
Good fit: Ideal candidates for this research are hospitalized children who have experienced cardiac arrest, particularly those with or at risk for pulmonary hypertension.
Not a fit: Patients who are adults or those who do not have cardiac arrest or pulmonary hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase survival rates for children experiencing cardiac arrest associated with pulmonary hypertension.
How similar studies have performed: Previous studies have shown promising results using similar approaches in animal models, indicating potential for success in human applications.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Morgan, Ryan William — Children's Hosp of Philadelphia
- Study coordinator: Morgan, Ryan William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.