Improving survival rates after out-of-hospital cardiac arrest through better medication timing and delivery
Official title: Optimizing the Timing and Route of Antiarrhythmic Administration in Out-of-Hospital Cardiac Arrest
Funded at Oregon Health & Science University · NIH-10864721 · Data updated 2026-11-12
This study is looking at whether giving a heart medication called amiodarone sooner and in a different order can help people who have a cardiac arrest due to certain heart rhythms, with the goal of improving their chances of survival and recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $191,365 |
| NIH project number | 1K23HL173647-01 |
| Project ID | NIH-10864721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced out-of-hospital cardiac arrest due to ventricular fibrillation or pulseless ventricular tachycardia.
✕Less likely to help
Patients who have cardiac arrest due to causes other than ventricular fibrillation or pulseless ventricular tachycardia may not benefit from this research.
What this research studies
This research investigates how the timing and method of administering antiarrhythmic medications, specifically amiodarone, can affect survival rates in patients who experience out-of-hospital cardiac arrest due to ventricular fibrillation or pulseless ventricular tachycardia. The study aims to determine if giving these medications earlier and in a different sequence can lead to better outcomes compared to current treatment guidelines. By conducting a pilot trial, the research will assess the impact of these changes on patient survival and overall recovery. Patients experiencing cardiac arrest may benefit from this research as it seeks to optimize emergency treatment protocols.
Why it matters
Potential benefit: If successful, this research could significantly increase survival rates for patients experiencing out-of-hospital cardiac arrest.
How similar studies have gone: Previous research has shown that optimizing medication timing in emergency situations can improve patient outcomes, suggesting potential success for this approach.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Lupton, Joshua — Oregon Health & Science University
- Study coordinator: Lupton, Joshua
Related research
Other NIH-funded projects on the same topics.
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Multi-center study on how ventilation during CPR relates to cardiac arrest outcomes
A large, real-world study will look at how ventilation during CPR affects survival after out-of-hospital cardiac arrest in adults.
-
Specialized post-arrest care after cardiac arrest
A large, nationwide effort tests whether transferring cardiac arrest patients to a specialized post-arrest care center improves recovery compared with usual care.
-
Reduce bias in predicting brain recovery after cardiac arrest
This project aims to make brain-recovery predictions more accurate for people who survive cardiac arrest by comparing outcomes between the United States and Brazil.
-
Fairer brain recovery predictions after cardiac arrest through U.S.–Brazil collaboration
This project aims to find better ways to predict brain recovery for people who survive cardiac arrest but have possible brain injury.
-
Improving predictions of brain recovery after cardiac arrest
This project compares outcomes after cardiac arrest in the U.S. and Brazil to learn which tests best predict who will regain brain function for people who survive cardiac arrest.
-
Reducing biased predictions of brain recovery after cardiac arrest
This project looks at cardiac arrest survivors in the US and Brazil to find more accurate ways to predict brain recovery and avoid premature stopping of life support.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.