Improving survival rates after out-of-hospital cardiac arrest through better medication timing and delivery
Optimizing the Timing and Route of Antiarrhythmic Administration in Out-of-Hospital Cardiac Arrest
This study is looking at whether giving a heart medication called amiodarone sooner and in a different order can help people who have a cardiac arrest due to certain heart rhythms, with the goal of improving their chances of survival and recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10864721 on NIH RePORTER |
What this research studies
This research investigates how the timing and method of administering antiarrhythmic medications, specifically amiodarone, can affect survival rates in patients who experience out-of-hospital cardiac arrest due to ventricular fibrillation or pulseless ventricular tachycardia. The study aims to determine if giving these medications earlier and in a different sequence can lead to better outcomes compared to current treatment guidelines. By conducting a pilot trial, the research will assess the impact of these changes on patient survival and overall recovery. Patients experiencing cardiac arrest may benefit from this research as it seeks to optimize emergency treatment protocols.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced out-of-hospital cardiac arrest due to ventricular fibrillation or pulseless ventricular tachycardia.
Not a fit: Patients who have cardiac arrest due to causes other than ventricular fibrillation or pulseless ventricular tachycardia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase survival rates for patients experiencing out-of-hospital cardiac arrest.
How similar studies have performed: Previous research has shown that optimizing medication timing in emergency situations can improve patient outcomes, suggesting potential success for this approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Lupton, Joshua — Oregon Health & Science University
- Study coordinator: Lupton, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.