Improving survival of retinal cells and optic nerve healing using immune cells
Enhancement of RGC survival and Optic Nerve Regeneration by Cytokine Polarized Myeloid Cells
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11045192
This study is looking at how certain immune cells can help protect and heal the optic nerve, which is important for vision, to find new ways to help people with optic nerve injuries from trauma or glaucoma.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11045192 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the survival of retinal ganglion cells (RGCs) and promoting the regeneration of the optic nerve, which are crucial for vision. It explores the use of immune cells, specifically cytokine-polarized myeloid cells, to harness the body's natural healing processes. By investigating how these immune cells can support the repair of damaged optic nerves, the research aims to develop new therapeutic strategies for individuals suffering from optic nerve injuries due to trauma or glaucoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 21 years old who have experienced optic nerve injuries or conditions like glaucoma that affect their vision.
Not a fit: Patients with optic nerve injuries that are not amenable to regenerative therapies or those with conditions unrelated to optic nerve damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore vision in patients with optic nerve injuries.
How similar studies have performed: Previous research has shown promise in using immune-driven healing strategies in animal models, suggesting potential for success in this novel approach.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEGAL, BENJAMIN M — OHIO STATE UNIVERSITY
- Study coordinator: SEGAL, BENJAMIN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.