Improving Stem Cell Treatment for Gum Disease
Specialized Proresolving Lipid Mediator-Enhanced Stem Cell Therapy and Tissue Regeneration
This project explores how special natural substances can help stem cells better heal gum disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11196782 on NIH RePORTER |
What this research studies
Periodontal disease is a common and serious problem where ongoing inflammation damages gum tissues and bone. Current treatments often struggle because they don't fully address this inflammation, limiting how well tissues can regrow. This project looks at natural substances called Specialized Proresolving lipid Mediators (SPMs), like Maresin 1, which help the body calm inflammation and promote healing. Researchers are combining these SPMs with human stem cells from the gums to see if they can improve tissue repair, including bone. The goal is to find new ways to regenerate damaged gum tissues more effectively for patients.
Who could benefit from this research
Good fit: Patients with chronic gum disease who have experienced significant tissue and bone loss might eventually benefit from this type of treatment.
Not a fit: Patients with mild gum inflammation or those without significant tissue damage may not be the primary focus for this advanced regenerative approach.
Why it matters
Potential benefit: If successful, this approach could lead to more effective treatments for severe gum disease, helping patients regrow lost gum and bone tissue.
How similar studies have performed: While the specific combination of Maresin 1-enhanced stem cell therapy is novel, individual components like Specialized Proresolving lipid Mediators (SPMs) have shown promise in experimental models and clinical trials for inflammation-related conditions.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Rakian, Audrey — University of Texas Hlth Science Center
- Study coordinator: Rakian, Audrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.