Improving stem cell transplants for treating blood disorders
Optimizing hematopoietic stem cell transplantation to treat non-malignant disease
This study is looking at new ways to make stem cell transplants safer and more effective for people with blood disorders like sickle cell disease, and it may involve patients trying out these improved methods.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10984824 on NIH RePORTER |
What this research studies
This research focuses on enhancing hematopoietic stem cell transplantation (HSCT) techniques to treat non-malignant blood diseases, such as sickle cell disease. The approach involves optimizing the conditioning process, mobilizing stem cells effectively, and utilizing therapeutic gene editing to improve patient outcomes. By leveraging advanced immunological techniques and antibody-drug conjugates, the research aims to make HSCT safer and more effective for patients with these conditions. Patients may be involved in trials that assess the efficacy of these new methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from non-malignant hematologic diseases, particularly those with sickle cell disease.
Not a fit: Patients with malignant blood disorders or those who do not have hematologic diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatments for patients with non-malignant blood disorders.
How similar studies have performed: Previous research has shown promise in optimizing HSCT techniques, indicating that this approach has potential based on earlier successes.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Persaud, Stephen Phillip — Washington University
- Study coordinator: Persaud, Stephen Phillip
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.