Improving spinal cord models using advanced 3D printing techniques.
Official title: Refining iPSC-Based Spinal Cord Model Systems by Fabricating Developmentally Programmed Extracellular Matrix Cues
Funded at Northwestern University at Chicago · NIH-10852169 · Data updated 2026-11-12
This study is exploring new ways to grow and support nerve cells in the spinal cord using special stem cells and a lab-made environment that feels like their natural home, which could help us learn more about nerve diseases and improve treatments for people with conditions affecting the central nervous system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $559,496 |
| NIH project number | 1R01AG086270-01 |
| Project ID | NIH-10852169 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with neurodegenerative disorders or those interested in advancements in spinal cord research.
✕Less likely to help
Patients with acute spinal cord injuries or those not affected by neurodegenerative conditions may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing models of the spinal cord by utilizing induced pluripotent stem cells (iPSCs) and developing a specialized extracellular matrix (ECM) that mimics natural conditions. By creating a more realistic environment for neurons, the study aims to improve their growth and functionality, which is crucial for understanding neurodevelopment and diseases affecting the central nervous system. Patients may benefit from insights gained into degenerative neurological disorders as the research seeks to overcome current limitations in studying adult-onset conditions. The approach combines advanced 3D printing technology with biological modeling to create a more effective platform for research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurodegenerative diseases.
How similar studies have gone: Previous research has shown promise in using iPSC technologies and ECM modeling, indicating potential for success in this innovative approach.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kiskinis, Evangelos — Northwestern University at Chicago
- Study coordinator: Kiskinis, Evangelos
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.