Improving spinal cord models using advanced 3D printing techniques.
Refining iPSC-Based Spinal Cord Model Systems by Fabricating Developmentally Programmed Extracellular Matrix Cues
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10852169
This study is exploring new ways to grow and support nerve cells in the spinal cord using special stem cells and a lab-made environment that feels like their natural home, which could help us learn more about nerve diseases and improve treatments for people with conditions affecting the central nervous system.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10852169 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing models of the spinal cord by utilizing induced pluripotent stem cells (iPSCs) and developing a specialized extracellular matrix (ECM) that mimics natural conditions. By creating a more realistic environment for neurons, the study aims to improve their growth and functionality, which is crucial for understanding neurodevelopment and diseases affecting the central nervous system. Patients may benefit from insights gained into degenerative neurological disorders as the research seeks to overcome current limitations in studying adult-onset conditions. The approach combines advanced 3D printing technology with biological modeling to create a more effective platform for research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neurodegenerative disorders or those interested in advancements in spinal cord research.
Not a fit: Patients with acute spinal cord injuries or those not affected by neurodegenerative conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in using iPSC technologies and ECM modeling, indicating potential for success in this innovative approach.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KISKINIS, EVANGELOS — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: KISKINIS, EVANGELOS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.