Improving sleep to enhance cognition in early Alzheimer's disease using trazodone
RCT Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (Rest)
['FUNDING_R01'] · JOHNS HOPKINS UNIVERSITY · NIH-10909076
This study is looking at whether taking trazodone to help improve sleep can also boost memory and thinking skills in people with early Alzheimer's disease, and we’d love for you to join us to see if better sleep can make a difference!
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10909076 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of trazodone, a medication commonly used to improve sleep, on cognitive function in individuals with early Alzheimer's disease. The study will involve a rigorous double-blind, placebo-controlled, randomized crossover trial to assess how better sleep can influence memory and cognitive abilities. By focusing on enhancing slow wave sleep, which is crucial for memory formation, the research aims to determine if improving sleep can slow the progression of Alzheimer's disease. Participants will be monitored for changes in cognitive function and sleep patterns throughout the trial.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early Alzheimer's disease who experience sleep disturbances.
Not a fit: Patients with advanced Alzheimer's disease or those without sleep issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving cognition and slowing the progression of Alzheimer's disease through better sleep management.
How similar studies have performed: Previous studies have shown that improving sleep can have positive effects on cognitive function in Alzheimer's patients, suggesting this approach may be promising.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GREENBERG, BARRY DAVID — JOHNS HOPKINS UNIVERSITY
- Study coordinator: GREENBERG, BARRY DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome