Improving sleep quality in veterans with PTSD using vagal nerve stimulation
Official title: Transcutaneous vagal nerve stimulation improvement of sleep quality in veterans with PTSD with or without history of mild TBI
Funded at Veterans Health Administration · NIH-11125742 · Data updated 2026-11-12
This study is looking at how a gentle electrical stimulation technique can help veterans with PTSD sleep better, especially those who may also have had a mild brain injury, by improving their sleep patterns and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | October 1, 2019 |
| Project end | September 30, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01RX003140-06 |
| Project ID | NIH-11125742 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with PTSD, particularly those who may also have a history of mild traumatic brain injury.
✕Less likely to help
Patients without PTSD or those who do not meet the criteria for participation in the study may not receive any benefit from this research.
What this research studies
This research investigates the use of transcutaneous vagal nerve stimulation to enhance sleep quality in veterans suffering from post-traumatic stress disorder (PTSD), with or without a history of mild traumatic brain injury (mTBI). The approach focuses on addressing disrupted sleep patterns commonly experienced by these individuals, such as frequent awakenings and altered sleep stages. By targeting the autonomic nervous system, the study aims to alleviate symptoms associated with PTSD and improve overall health outcomes. Participants will be monitored for changes in sleep quality and related health metrics throughout the study period.
Why it matters
Potential benefit: If successful, this research could lead to improved sleep quality and overall well-being for veterans with PTSD.
How similar studies have gone: Previous research has shown promise in using vagal nerve stimulation for various conditions, suggesting potential for success in this novel application for PTSD.
Where this research is happening
-
Veterans Health Administration
Gainesville, United States Active
Researchers
- Principal investigator: Williamson, John B — Veterans Health Administration
- Study coordinator: Williamson, John B
Related research
Other NIH-funded projects on the same topics.
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-
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Identifying brain proteins linked to PTSD and alcohol use disorder
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-
Transdiagnostic Behavior Therapy for Veterans with Social Anxiety and PTSD Symptoms
A clinical trial tests whether a flexible brain-behavior therapy helps veterans with social anxiety and PTSD symptoms feel better and engage more in daily life.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.