Improving sleep and cognition in children with Down syndrome using medications.

Who could benefit from this research

What this research studies

This research investigates the use of a combination of medications, atomoxetine and oxybutynin, to treat obstructive sleep apnea (OSA) in children with Down syndrome. OSA is common in these children and can lead to cognitive impairments and reduced quality of life. The study aims to determine if this medication combination can improve airway tone during sleep, thereby alleviating OSA symptoms and enhancing cognitive function. By focusing on a well-tolerated treatment option, the research seeks to provide a viable alternative to current therapies that may not be effective for all patients.

Why it matters

Where this research is happening

• University of Arizona
  Tucson, United States Active

Researchers

• Principal investigator: Combs, Daniel — University of Arizona
• Study coordinator: Combs, Daniel

Related research

Other NIH-funded projects on the same topics.

• Medications to treat sleep apnea and boost thinking in children with Down syndrome

  This project gives a combination of two commonly used medicines, atomoxetine and oxybutynin, to children with Down syndrome who have obstructive sleep apnea to see if it helps them sleep better and think more clearly.

  NIH research University of Arizona · Tucson, United States · NIH-11178895

• Personalized DISE-guided surgery for sleep apnea in children with Down syndrome

  A personalized surgical approach guided by DISE sleep-endoscopy is being tested to better treat sleep apnea in children with Down syndrome who don’t always improve after standard surgery.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11422377

• Oxygen therapy for kids with Down syndrome and sleep apnea

  A study tests whether low-flow oxygen helps children with Down syndrome and moderate to severe obstructive sleep apnea who have not benefited from first-line surgery.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11411366

• Low-flow nighttime oxygen for children and teens with Down syndrome and sleep apnea

  This project tests whether nightly low-flow oxygen helps children and adolescents with Down syndrome who have moderate to severe obstructive sleep apnea.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-11193933

• Testing oxygen therapy for children with Down Syndrome and sleep apnea

  This study is looking at whether low-flow oxygen therapy can help kids and teens with Down Syndrome who have trouble breathing while sleeping, aiming to see if it can make them feel better and improve their daily lives, especially for those who haven't found relief with other treatments.

  NIH research Cincinnati Childrens Hosp Med Ctr · Cincinnati, United States · NIH-10972922

• Personalized surgery for sleep apnea in children with Down syndrome

  This trial will see if using sleep endoscopy to guide personalized airway surgery helps children with Down syndrome who have obstructive sleep apnea.

  NIH research Oregon Health & Science University · Portland, United States · NIH-10972917

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.