Improving sleep and brain health in older adults with Alzheimer's disease
Official title: Improving Sleep and AD Biomarkers: A Pilot RCT of Citicoline
Funded at Emory University · NIH-10770497 · Data updated 2026-11-12
This study is looking at how a supplement called Citicoline might help improve sleep and brain function in older adults who have mild cognitive impairment or Alzheimer's disease, to see if better sleep can make a positive difference in their overall health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $421,801 |
| NIH project number | 5R61AG080606-02 |
| Project ID | NIH-10770497 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults diagnosed with mild cognitive impairment or Alzheimer's disease who experience sleep disturbances.
✕Less likely to help
Patients without cognitive impairment or those who do not experience sleep issues may not benefit from this research.
What this research studies
This research investigates the effects of Citicoline, a compound that may enhance brain function, on sleep disturbances in older adults with mild cognitive impairment and Alzheimer's disease. The study aims to understand how improving sleep can potentially modify the neurobiology of Alzheimer's, particularly focusing on the cholinergic system, which is crucial for sleep regulation. Participants will be monitored for changes in sleep patterns and cognitive function as they receive Citicoline treatment over the course of the study.
Why it matters
Potential benefit: If successful, this research could lead to improved sleep quality and cognitive function in patients with Alzheimer's disease.
How similar studies have gone: Previous studies have shown promising results in improving cognitive function with similar interventions, indicating potential for success in this approach.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Pak, Victoria M — Emory University
- Study coordinator: Pak, Victoria M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.