Improving Skin Grafts for Recessive Dystrophic Epidermolysis Bullosa
Chromatin Dynamics During Epithelial Commitment
This project aims to make better skin grafts from stem cells to help patients with severe skin blistering from Recessive Dystrophic Epidermolysis Bullosa.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11175458 on NIH RePORTER |
What this research studies
We are developing a special system that uses stem cells to create skin grafts for patients with Recessive Dystrophic Epidermolysis Bullosa, a condition causing severe skin wounds. This system creates different skin layers, including surface skin, underlying tissue, and pigment cells. Our goal is to understand how these skin cells develop and interact at a very basic level, focusing on how their genetic material is organized. By learning more about these processes, we hope to improve how we make these skin grafts, making them more effective and consistent for patients.
Who could benefit from this research
Good fit: Patients with Recessive Dystrophic Epidermolysis Bullosa who suffer from non-healing wounds are the ultimate beneficiaries of this foundational research.
Not a fit: Patients without Recessive Dystrophic Epidermolysis Bullosa or similar severe skin conditions would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to more reliable and effective stem cell-derived skin grafts for treating the chronic wounds experienced by patients with Recessive Dystrophic Epidermolysis Bullosa.
How similar studies have performed: Previous work has identified key factors involved in skin cell differentiation, and this project builds upon those findings to refine the manufacturing process of skin grafts.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Oro, Anthony E — Stanford University
- Study coordinator: Oro, Anthony E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.