Improving single-cell genome sequencing for cancer research
Accessible high-throughput single-cell genome sequencing
This study is working on making it easier and faster to look at the DNA of individual cancer cells, which can help us find out how cancer changes and why some treatments don’t work, ultimately aiming to improve cancer care for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10819200 on NIH RePORTER |
What this research studies
This research aims to enhance the accessibility and efficiency of single-cell whole genome sequencing (scWGS) to better understand cancer evolution and resistance to treatments. By developing new technologies that utilize common laboratory equipment and readily available reagents, the project seeks to significantly increase the number of cells that can be analyzed and the genomic information obtained from each cell. This approach will help identify rare tumor subpopulations that may be resistant to therapies, providing valuable insights for cancer treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with solid tumors who may benefit from advanced genomic analysis to inform their treatment options.
Not a fit: Patients with non-solid tumors or those not undergoing treatment for cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments by identifying and targeting resistant tumor subpopulations.
How similar studies have performed: Previous research has shown promise in using single-cell sequencing technologies, indicating that this approach could lead to significant advancements in cancer genomics.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Adey, Andrew — Oregon Health & Science University
- Study coordinator: Adey, Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.