Improving sensitivity in advanced EPR spectroscopy techniques
Official title: Large-Volume Dielectric Resonators for mm-Wave Pulsed EPR
Funded at North Carolina State University Raleigh · NIH-11065471 · Data updated 2026-11-12
This study is working on improving a special technique called Pulse Electron Paramagnetic Resonance (EPR) to help scientists learn more about complex molecules in our bodies, which could eventually lead to better treatments for various diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | May 1, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $482,409 |
| NIH project number | 5R01GM153951-02 |
| Project ID | NIH-11065471 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions related to biochemical imbalances or diseases involving metalloenzymes.
✕Less likely to help
Patients with conditions unrelated to biochemical processes or those not involving metalloenzymes may not receive direct benefits from this research.
What this research studies
This research focuses on enhancing the sensitivity of Pulse Electron Paramagnetic Resonance (EPR) spectroscopy, a powerful tool used in biochemistry and structural biology. By developing large-volume dielectric resonators, the project aims to increase the concentration sensitivity of pulse EPR methods, which are essential for studying complex biomolecules and metalloenzymes. Patients may benefit indirectly as this advancement could lead to better understanding and treatment of biochemical processes related to various diseases. The research employs established EPR techniques to gather detailed information about molecular interactions and structures.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases by providing deeper insights into biochemical processes.
How similar studies have gone: Previous research has shown success in enhancing EPR techniques, but this specific approach to increasing sensitivity is novel.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Smirnov, Alex I. — North Carolina State University Raleigh
- Study coordinator: Smirnov, Alex I.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.