Improving seizure control in glioma patients with IDH mutations
Targeting IDH mutations to improve seizure control in glioma patients
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10840901
This study is looking at how blocking certain genetic changes in glioma tumors might help reduce seizures in patients, making it easier for them to manage their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10840901 on ClinicalTrials.gov |
What this research studies
This research investigates how targeting specific genetic mutations in glioma tumors can help control seizures in patients. Glioma patients often experience seizures, and current treatments are not effective for many. The study focuses on the role of a substance produced by these tumors that mimics a neurotransmitter, which may increase seizure activity. By using an enzyme inhibitor to block this effect, the researchers aim to reduce seizure frequency and improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with diffusely infiltrative glioma who experience seizures.
Not a fit: Patients with glioma who do not experience seizures or have other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective seizure control for glioma patients, improving their quality of life.
How similar studies have performed: Previous research has shown promising results in targeting similar genetic mutations to improve treatment outcomes in other conditions, suggesting potential for success in this approach.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HORBINSKI, CRAIG MICHAEL — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: HORBINSKI, CRAIG MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.