Improving saRNA vaccine stability to ease cold storage for COVID-19 vaccines
Official title: Improving the Stability of saRNA LNP Formulations To Overcome Cold Chain Challenges
Funded at Keylicon Biosciences INC · NIH-11406435 · Data updated 2026-11-12
Aimed at making saRNA coronavirus vaccines more stable at higher temperatures so it’s easier to store, ship, and use.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Keylicon Biosciences INC NIH-funded |
| Lab location | 1 site (Brookline, United States) |
| Project start | September 7, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $400,000 |
| NIH project number | 1R43EB038819-01A1 |
| Project ID | NIH-11406435 on NIH RePORTER |
Who could benefit from this research
✓Could help
Any patient populations that would benefit from easier-to-distribute RNA vaccines, including those in areas with limited cold-chain infrastructure.
✕Less likely to help
Patients in regions with robust cold-chain capacity may see less impact from these improvements.
What this research studies
This project focuses on saRNA vaccine formulations that could stay stable longer without strict cold-chain requirements. By improving stability, it could help produce and distribute vaccines more efficiently, especially in settings with limited refrigeration. The work involves formulation tweaks and testing to balance immune response with tolerability while reducing dose needs. If successful, it could lower waste and speed up access to vaccines during outbreaks.
Why it matters
Potential benefit: If successful, vaccines could be easier to store and distribute, reducing waste and enabling faster, broader protection.
How similar studies have gone: Previous RNA vaccine work showed strong immunogenicity; this project focuses on stability improvements to enable real-world use.
Where this research is happening
-
Keylicon Biosciences INC
Brookline, United States Active
Researchers
- Principal investigator: Mcgee, Joshua — Keylicon Biosciences INC
- Study coordinator: Mcgee, Joshua
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.