Improving RNA sequencing to better understand gene expression and disease
Official title: High-Resolution Pseudouridine and m6A Sequencing Through Advanced Nanopore Adduct Analysis
Funded at Electronic Biosciences, INC. · NIH-11065238 · Data updated 2026-11-12
This study is working on new ways to better understand important changes in RNA that can affect how our genes work, which could help improve treatments for various health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Electronic Biosciences, INC. NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | June 1, 2025 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $350,000 |
| NIH project number | 1R41GM157757-01 |
| Project ID | NIH-11065238 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with conditions influenced by RNA modifications, such as certain cancers and other diseases related to gene expression.
✕Less likely to help
Patients with conditions unrelated to RNA modifications or those not requiring RNA-based diagnostics may not benefit from this research.
What this research studies
This research focuses on enhancing RNA sequencing technologies to accurately detect important RNA modifications, specifically pseudouridine and N6-methyladenosine. By developing advanced nanopore sequencing techniques, the project aims to concurrently analyze these modifications, which play critical roles in gene regulation and cellular responses to stress. This innovative approach seeks to overcome current limitations in RNA sequencing accuracy and precision, potentially leading to better diagnostics and therapeutics for various diseases. Patients may benefit from improved understanding and treatment options for conditions influenced by these RNA modifications.
Why it matters
Potential benefit: If successful, this research could lead to more accurate RNA-based diagnostics and targeted therapies for diseases related to RNA modifications.
How similar studies have gone: While RNA sequencing is a well-established field, the specific approach of using advanced nanopore technology for concurrent detection of multiple RNA modifications is relatively novel and has not been extensively tested.
Where this research is happening
-
Electronic Biosciences, INC.
San Diego, United States Active
Researchers
- Principal investigator: Ervin, Eric — Electronic Biosciences, INC.
- Study coordinator: Ervin, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.