Improving resilience to Alzheimer's disease by enhancing brain cell growth
Official title: Resilience to Alzheimer's disease by targeting adult hippocampal neurogenesis
Funded at Massachusetts General Hospital · NIH-10983913 · Data updated 2026-11-12
This study is looking at how encouraging the growth of new brain cells might help fight Alzheimer's disease, and it's for anyone interested in new ways to improve memory and thinking skills in people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,173,794 |
| NIH project number | 1RF1AG085291-01A1 |
| Project ID | NIH-10983913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's who do not exhibit significant cognitive impairment may not benefit from this research.
What this research studies
This research investigates how boosting the growth of new neurons in the adult brain can help combat Alzheimer's disease. It focuses on understanding the relationship between adult hippocampal neurogenesis (the process of forming new neurons) and brain-derived neurotrophic factor (a protein that supports neuron health). By studying mice that model Alzheimer's pathology, the researchers aim to find ways to enhance both neurogenesis and the levels of this supportive protein, potentially leading to new treatments for cognitive decline associated with Alzheimer's.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that slow down cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous research has shown promising results in enhancing neurogenesis as a potential therapeutic strategy for Alzheimer's disease, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Choi, Se Hoon — Massachusetts General Hospital
- Study coordinator: Choi, Se Hoon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.