Improving rehabilitation for veterans with chronic psychosis using brain biomarkers
Official title: Optimization of Neurophysiologic Biomarkers for Rehabilitation Interventions in Veterans with Chronic Psychosis
Funded at VA San Diego Healthcare System · NIH-10916447 · Data updated 2026-11-12
This study is looking to find a new way to measure brain activity that can help veterans with schizophrenia get better support in their recovery, so they can improve their thinking skills and overall well-being through personalized training.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK2RX004570-02 |
| Project ID | NIH-10916447 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with schizophrenia who experience cognitive impairments.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those who do not experience cognitive impairments may not benefit from this research.
What this research studies
This research focuses on developing a new biomarker related to brain function to enhance rehabilitation efforts for veterans suffering from schizophrenia. By identifying specific brain activity patterns, the study aims to determine which veterans are most likely to benefit from targeted cognitive training interventions. The approach combines clinical neuroscience with precision rehabilitation, aiming to improve cognitive function and overall quality of life for participants. The research is part of a career development program for an early career psychiatrist dedicated to advancing veterans' health.
Why it matters
Potential benefit: If successful, this research could lead to more effective rehabilitation strategies for veterans with chronic psychosis, improving their cognitive function and quality of life.
How similar studies have gone: While the concept of using biomarkers for cognitive rehabilitation is emerging, this specific approach is novel and has not been extensively tested in similar studies.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Molina, Juan — VA San Diego Healthcare System
- Study coordinator: Molina, Juan
Related research
Other NIH-funded projects on the same topics.
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Psychosis in diverse settings across the world
This project studies how psychotic disorders show up and respond to treatment in adults with diverse backgrounds, including populations in Africa, the Caribbean, and other Global South settings.
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Psychosis in Diverse Settings: Understanding Symptoms and Treatment Across Global South
A human-facing study will look at how psychotic disorders present and respond to treatment in adults from Africa, the Caribbean, and other Global South settings, using genetic and clinical data.
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A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Genetic clues for early-onset psychosis in Latino youth
This project looks at the genes of young people with early-onset psychosis and compares them with similar youths without psychosis to find genetic factors that contribute to the illness.
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Biomarkers to tailor rehab for Veterans with schizophrenia
A clinician-scientist is developing a brain-based biomarker to guide personalized rehabilitation for Veterans with schizophrenia.
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Computational analysis of facial expression in early psychosis
Aims to develop computer-based measures of facial expression in people at risk for or with schizophrenia to help track symptoms and guide future trials.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.