Improving recovery from injury and surgery by targeting immune cells
Myeloid lineage targeting to improve recovery from injury and surgery: Cellular and molecular mechanisms
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-11137187
This study is looking at how certain immune cells help the body heal after injuries and surgeries, using mice to learn more about their role, with the hope of finding better ways to help people recover faster and avoid complications like chronic pain.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-11137187 on ClinicalTrials.gov |
What this research studies
This research investigates how specific immune cells, particularly those of myeloid lineage, respond to injury and surgery, and how their manipulation can enhance recovery. By using a mouse model that mimics human orthopedic injuries, the study aims to identify the critical roles these immune cells play in healing processes. The researchers will explore the timing and function of these cells to understand how prolonged immune activation can lead to complications like chronic pain and delayed healing. The ultimate goal is to find new strategies to improve patient outcomes after injuries and surgeries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals recovering from orthopedic injuries or surgeries who experience delayed healing or chronic pain.
Not a fit: Patients with non-orthopedic injuries or those not experiencing complications from their recovery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery strategies for patients suffering from injuries and surgical procedures, potentially reducing pain and enhancing healing.
How similar studies have performed: Other research has shown promise in manipulating immune responses to improve healing, suggesting that this approach could yield significant insights.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAWFIK, VIVIANNE L — STANFORD UNIVERSITY
- Study coordinator: TAWFIK, VIVIANNE L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Functional disorder