Improving recovery for people with long-term effects of COVID-19.

Evaluating a Comprehensive Multimodal Outpatient Rehabilitation Program to Improve the Functioning of Persons Suffering from Post-acute Sequelae of SARS-CoV-2 infection (PASC): A Randomized Controlled

NIH-funded research University of Pennsylvania · NIH-11061802

This study is testing a special six-week rehab program for people dealing with ongoing symptoms after COVID-19, aiming to help them feel better and improve their health in a way that fits their individual needs.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11061802 on NIH RePORTER

What this research studies

This research investigates a comprehensive rehabilitation program designed for individuals experiencing long-term symptoms after COVID-19, known as post-acute sequelae of SARS-CoV-2 infection (PASC). The program aims to address the diverse and persistent symptoms that affect various body systems through a patient-centered, interdisciplinary approach. Participants will engage in a six-week multimodal therapy regimen tailored to their specific needs, with the goal of improving their overall health and functioning. The study will also assess the costs associated with this rehabilitation intervention to understand its effectiveness and feasibility for broader implementation.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals who have contracted COVID-19 and are experiencing persistent symptoms lasting beyond the acute phase.

Not a fit: Patients who have not contracted COVID-19 or those without long-term symptoms related to the virus may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly enhance the quality of life for patients suffering from long-term COVID-19 symptoms.

How similar studies have performed: Previous research on rehabilitation programs for chronic conditions has shown promise, indicating that a similar approach for PASC may also yield positive outcomes.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions acute infectionadverse sequelae of coronavirus diseaseadverse sequelae of coronavirus disease 2019
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.