Improving recovery after stroke through enhanced mitochondrial function
Enhanced Mitochondrial Function Increases Effectiveness of Post-Stroke Rehabilitation
This study is looking at how a special compound called HPβCD might help stroke patients recover better by reducing inflammation and improving the health of their cells, which could lead to better movement and thinking skills during their rehabilitation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Arizona VA Health Care System NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project ID | NIH-10999058 on NIH RePORTER |
What this research studies
This research investigates how a compound called 2-hydroxypropyl-β-cyclodextrin (HPβCD) can help reduce tissue damage and improve rehabilitation outcomes for stroke patients. The approach focuses on removing harmful lipid debris that contributes to inflammation and restoring mitochondrial function in immune cells after a stroke. By administering HPβCD, the study aims to enhance motor recovery and cognitive function during rehabilitation. The research is based on previous findings that suggest HPβCD can mitigate chronic inflammation and support neuronal health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently experienced a stroke and are undergoing rehabilitation.
Not a fit: Patients who have not had a stroke or those with advanced neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation strategies for stroke survivors, enhancing their recovery and quality of life.
How similar studies have performed: Previous studies have shown promising results with similar approaches in reducing inflammation and improving recovery after stroke, indicating potential for success.
Where this research is happening
Tucson, United States
- Southern Arizona VA Health Care System — Tucson, United States (Active)
Researchers
- Principal investigator: Schnellmann, Rick G — Southern Arizona VA Health Care System
- Study coordinator: Schnellmann, Rick G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.