Improving recovery after stroke through enhanced mitochondrial function
Official title: Enhanced Mitochondrial Function Increases Effectiveness of Post-Stroke Rehabilitation
Funded at Southern Arizona VA Health Care System · NIH-10999058 · Data updated 2026-11-12
This study is looking at how a special compound called HPβCD might help stroke patients recover better by reducing inflammation and improving the health of their cells, which could lead to better movement and thinking skills during their rehabilitation.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Southern Arizona VA Health Care System NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 1, 2019 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| NIH project number | 2I01RX003224-05A2 |
| Project ID | NIH-10999058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently experienced a stroke and are undergoing rehabilitation.
✕Less likely to help
Patients who have not had a stroke or those with advanced neurological conditions may not benefit from this research.
What this research studies
This research investigates how a compound called 2-hydroxypropyl-β-cyclodextrin (HPβCD) can help reduce tissue damage and improve rehabilitation outcomes for stroke patients. The approach focuses on removing harmful lipid debris that contributes to inflammation and restoring mitochondrial function in immune cells after a stroke. By administering HPβCD, the study aims to enhance motor recovery and cognitive function during rehabilitation. The research is based on previous findings that suggest HPβCD can mitigate chronic inflammation and support neuronal health.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation strategies for stroke survivors, enhancing their recovery and quality of life.
How similar studies have gone: Previous studies have shown promising results with similar approaches in reducing inflammation and improving recovery after stroke, indicating potential for success.
Where this research is happening
-
Southern Arizona VA Health Care System
Tucson, United States Active
Researchers
- Principal investigator: Schnellmann, Rick G — Southern Arizona VA Health Care System
- Study coordinator: Schnellmann, Rick G
Related research
Other NIH-funded projects on the same topics.
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Understanding how vagus nerve stimulation helps stroke recovery to guide better treatments
This NIH grant uses computer models to figure out how brief, task-timed vagus nerve stimulation affects the brain after stroke and helps movement recovery.
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Calcium imaging guides deep brain stimulation to boost chronic stroke recovery in a rat model
A research team is testing how customizing deep brain stimulation parameters in rats with stroke can improve long-term motor recovery, with the goal of guiding future patient treatments.
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Targeting synapse turnover to boost stroke recovery
Aims to find ways to shape brain rewiring after stroke by guiding how synapses grow, with the goal of helping adults recover upper-limb function.
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Wearable EMG-FES System to Help Stroke Recovery and Find Biological Markers
A wearable sleeve that uses your own muscle signals to help arm movement after stroke, while researchers look for biological clues that track recovery.
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Noradrenergic VNS to boost stroke rehab outcomes
A patient-oriented look at a therapy that combines brief vagus nerve stimulation with physical rehab to help people recover arm movement after a stroke.
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How rehab changes the brain after stroke
This project will look at how rehabilitation training changes brain activity and connections after stroke to help people regain movement.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.