Improving recovery after stroke in older adults using a specific drug approach
Activation of the RXR/PPARγ axis improves long-term outcomes after ischemic stroke in aged mice
This study is looking at how a certain pathway in the body can help older mice recover better after a stroke, using a safe, low-dose medication to improve healing and reduce inflammation, which could lead to new ways to help older people recover from strokes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11031320 on NIH RePORTER |
What this research studies
This research investigates how activating the RXR/PPARγ pathway can enhance recovery outcomes after ischemic stroke in older mice. The study focuses on the unique immune responses in aged individuals, which differ significantly from younger populations. By repurposing an FDA-approved drug at low doses, the research aims to balance the immune response to promote healing while reducing harmful inflammation. The findings could lead to new treatment strategies that harness the body's immune system to improve neurological recovery after stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly veterans, who have experienced an ischemic stroke.
Not a fit: Patients who are not elderly or who have not suffered an ischemic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and quality of life for older stroke patients by utilizing the body's immune system more effectively.
How similar studies have performed: While this approach is innovative, previous studies have shown promise in utilizing immune modulation for recovery after stroke, indicating potential for success.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Chen, Jun — Veterans Health Administration
- Study coordinator: Chen, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.