Improving recovery after stroke by targeting brain immune cells
Modulating microglia and macrophage functions to promote stroke recovery
This study is looking at how certain immune cells in the brain help people recover after a stroke, and it aims to find new ways to boost their healing powers, which could lead to better treatments for stroke recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11074654 on NIH RePORTER |
What this research studies
This research investigates how specific immune cells in the brain, called microglia and macrophages, contribute to recovery after a stroke. By understanding the signals that activate these cells, the study aims to identify new treatment strategies that can enhance their beneficial functions and promote brain repair. The research focuses on a key protein, STAT1, which may play a crucial role in regulating these immune responses during the recovery phase following a stroke. Patients may benefit from insights gained in this research that could lead to improved therapies for stroke recovery.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a stroke and are in the recovery phase.
Not a fit: Patients who have not had a stroke or are in the very acute phase of stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly enhance recovery and quality of life for stroke patients.
How similar studies have performed: Previous research has shown promising results in modulating immune responses for recovery after stroke, indicating that this approach has potential for success.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Shi, Yejie — University of Pittsburgh at Pittsburgh
- Study coordinator: Shi, Yejie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.