Improving recovery after stroke by targeting brain cell networks
Official title: Modulating cortical inhibitory networks to improve stroke recovery
Funded at Veterans Affairs Med Ctr San Francisco · NIH-10922794 · Data updated 2026-11-12
This study is looking at how certain brain cells that help control movement can be changed after a stroke to help people recover better, and it’s designed for stroke patients who want to improve their motor skills.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Affairs Med Ctr San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| NIH project number | 5IK2RX004558-02 |
| Project ID | NIH-10922794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke and are seeking ways to enhance their recovery process.
✕Less likely to help
Patients who have not had a stroke or those with severe cognitive impairments may not benefit from this research.
What this research studies
This research aims to enhance motor recovery in stroke patients by exploring how specific inhibitory cell networks in the brain contribute to motor learning. The project will investigate how these networks are affected by stroke and whether modifying their activity can lead to better recovery outcomes. Through a combination of experimental work and mentorship, the research seeks to fill knowledge gaps and develop new therapeutic strategies for stroke rehabilitation.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve motor recovery for stroke patients.
How similar studies have gone: Previous research has shown promise in modulating neural circuits for recovery, indicating that this approach could be effective.
Where this research is happening
-
Veterans Affairs Med Ctr San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Arroyo, Sergio Estevan — Veterans Affairs Med Ctr San Francisco
- Study coordinator: Arroyo, Sergio Estevan
Related research
Other NIH-funded projects on the same topics.
-
Stroke prevention with hydroxyurea for children with sickle cell anemia in Nigeria
A multinational, patient-facing study tests whether hydroxyurea can safely prevent first strokes in Nigerian children with sickle cell anemia.
-
Music-powered tools to boost blood pressure and stroke prevention for Nigerian youth and their older caregivers
This project uses popular music to help Nigerian youths and their older family members start and stick to blood pressure and stroke prevention habits.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
-
LRP1 controls NSC movement and stroke recovery
This NIH grant studies how a brain receptor called LRP1 helps neural stem cells move to stroke injuries and support recovery in adults.
-
BBB Dysfunction after Stroke and Risk for Dementia
A study at Stanford will look at whether inflammation after a stroke leads to leaky blood vessels and later dementia, by following stroke survivors and comparing them with people without stroke.
-
Improving blood flow after stroke by breaking down NETs
Aims to see if breaking down neutrophil extracellular traps (NETs) after an ischemic stroke can improve blood flow and reduce brain injury in patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.