Improving recovery after spinal cord injuries by targeting a specific receptor
Targeting Protease Activated Receptor 1 for Repair of the Injured Spinal Cord
This study is looking at how a specific protein called PAR1 affects recovery after spinal cord injuries, and it aims to find out if blocking this protein can help improve movement and reduce inflammation, which could lead to new treatments for people with spinal cord injuries.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10908517 on NIH RePORTER |
What this research studies
This research investigates the role of Protease Activated Receptor 1 (PAR1) in spinal cord injuries and how its modulation can enhance recovery. The study involves examining the effects of proteases on cellular functions and inflammation in the central nervous system. By using animal models, researchers aim to understand how inhibiting PAR1 can lead to better locomotor recovery and reduced inflammation after spinal cord injury. The findings could pave the way for new therapeutic strategies to promote neural protection and repair.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced acute spinal cord injuries.
Not a fit: Patients with chronic spinal cord injuries or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve recovery outcomes for patients with spinal cord injuries.
How similar studies have performed: Previous studies have shown promising results in targeting similar pathways for neural repair, indicating potential for success in this approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Scarisbrick, Isobel a — Mayo Clinic Rochester
- Study coordinator: Scarisbrick, Isobel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.