Improving recovery after severe limb injuries using neuromuscular junction therapies
Neuromuscular junction as a therapeutic target to improve post-traumatic outcomes
This study is looking at ways to help people recover better from serious limb injuries, especially those who have had a tourniquet applied, by understanding how muscle connections are affected and finding new treatments to improve healing and overall quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11059228 on NIH RePORTER |
What this research studies
This research investigates how to enhance recovery for patients suffering from severe limb injuries, particularly those who have undergone tourniquet treatment. It focuses on understanding the neuromuscular junction, which is crucial for muscle function, and how its disruption during injury can lead to long-term complications. By exploring specific signaling pathways involved in muscle recovery, the research aims to identify effective therapies that can mitigate the negative effects of tourniquet-related ischemia and reperfusion injuries. Patients may benefit from improved treatment options that enhance their recovery and quality of life after traumatic injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced severe limb injuries requiring tourniquet application.
Not a fit: Patients with non-traumatic muscle conditions or those who have not experienced tourniquet-related injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve recovery outcomes for patients with severe limb injuries.
How similar studies have performed: Previous research has shown promise in targeting neuromuscular junctions for recovery in similar injury contexts, indicating potential for success in this approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Li, Yu-Long — University of Nebraska Medical Center
- Study coordinator: Li, Yu-Long
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.