Improving recovery after lung surgery by targeting inflammation
Official title: Targeting a Defined Surgical Stress-Induced Inflammatory Pathway to Improve Peri-Operative Outcomes
Funded at University of Maryland Baltimore · NIH-11002689 · Data updated 2026-11-12
This study is looking at how inflammation impacts recovery for people having lung surgery, especially focusing on a type of white blood cell called eosinophils, to find ways to help patients heal better and avoid complications after their surgery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $503,935 |
| NIH project number | 5R01HL166402-03 |
| Project ID | NIH-11002689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients scheduled for lung resection surgery who may be at risk for postoperative respiratory complications.
✕Less likely to help
Patients who are not undergoing lung surgery or those with pre-existing severe respiratory conditions may not benefit from this research.
What this research studies
This research investigates how inflammation affects recovery in patients undergoing lung surgery. It focuses on the role of eosinophils, a type of white blood cell, which can increase during the perioperative period and lead to complications like respiratory distress. By studying this process in a small animal model, the researchers aim to understand how certain cytokines and corticosteroids influence eosinophil behavior and how manipulating these factors could improve patient outcomes. The ultimate goal is to identify strategies that can enhance recovery and reduce complications after lung resection.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and reduced complications for patients undergoing lung surgery.
How similar studies have gone: Other research has shown that targeting inflammatory pathways can lead to improved outcomes in surgical patients, suggesting potential success for this approach.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Krupnick, Alexander S. — University of Maryland Baltimore
- Study coordinator: Krupnick, Alexander S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.