Improving radiotherapy to better target cancer cells while protecting healthy tissues
Molecular Strategies to Widen the Therapeutic Index of Radiotherapy
This study is looking at ways to make radiotherapy safer and more effective for cancer patients by using information about tumors and the immune system, with a special focus on helping those with head and neck cancer and lung cancer to have fewer side effects.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10914184 on NIH RePORTER |
What this research studies
This research investigates how to enhance the effectiveness of radiotherapy by using knowledge of tumor genetics and the surrounding environment to protect healthy tissues from radiation damage. The approach includes modulating the body's immune response to improve treatment outcomes for cancer patients. Specific projects focus on reducing side effects like severe dry mouth in head and neck cancer patients and personalizing treatment strategies for lung cancer patients. The research aims to create a safer and more effective radiotherapy experience for patients.
Who could benefit from this research
Good fit: Ideal candidates include cancer patients undergoing radiotherapy, particularly those with head and neck cancer or non-small cell lung cancer.
Not a fit: Patients who are not undergoing radiotherapy or those with cancers not targeted by this research may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments with fewer side effects for patients undergoing radiotherapy.
How similar studies have performed: Previous research has shown promise in using similar strategies to enhance radiotherapy, indicating potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Le, Quynh-Thu Xuan — Stanford University
- Study coordinator: Le, Quynh-Thu Xuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.