Improving Radiation Treatment for Glioblastoma
Utilizing Radiation-Induced Multi-potency to Increase the Efficacy of Radiotherapy
This project looks for new ways to make radiation therapy more effective for people with glioblastoma, a serious type of brain cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11115575 on NIH RePORTER |
What this research studies
Glioblastoma is a very challenging brain cancer where current treatments, including radiation, often don't work well enough. We know that radiation can sometimes cause cancer cells to become more like stem cells, making them resistant to treatment and able to regrow the tumor. Our work aims to stop this process by using new compounds that can reach the brain and prevent these resistant cells from forming. We are also exploring if we can guide these cancer cells to mature and stop growing, making them easier to treat.
Who could benefit from this research
Good fit: This foundational research is focused on understanding and improving treatments for patients diagnosed with glioblastoma.
Not a fit: Patients with cancers other than glioblastoma may not directly benefit from this specific research, as it is highly focused on brain tumors.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that significantly improve the effectiveness of radiation treatment for glioblastoma patients, potentially extending their lives.
How similar studies have performed: Previous work has shown promising results in animal models, demonstrating that preventing radiation-induced stem cell changes can improve survival.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Pajonk, Frank — University of California Los Angeles
- Study coordinator: Pajonk, Frank
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.