Improving radiation therapy for tumors with low oxygen levels
Improved Radiation Therapy of Hypoxic Tumor Regions by Integrated PET, EPR, and MR Imaging - Resubmission 01
This study is looking at new ways to improve radiation therapy for tumors that don't respond well to treatment because they have low oxygen levels, and it's designed for patients who have these tough-to-treat tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10771144 on NIH RePORTER |
What this research studies
This research aims to enhance radiation therapy for tumors that are resistant to treatment due to low oxygen levels, known as hypoxic tumors. By using advanced imaging techniques, including positron emission tomography (PET) and electron paramagnetic resonance (EPR), the study seeks to accurately identify and target these resistant tumor regions. The approach involves delivering higher doses of radiation specifically to the hypoxic areas, which has shown promise in preliminary animal studies. Patients may benefit from more effective treatment options that could lead to better tumor control and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with malignant tumors that exhibit hypoxic characteristics.
Not a fit: Patients with tumors that are not hypoxic or those who do not require radiation therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved radiation therapy techniques that significantly enhance treatment outcomes for patients with hypoxic tumors.
How similar studies have performed: Previous studies have shown promise in using advanced imaging techniques for targeting hypoxic tumors, but this specific integrated approach is relatively novel.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Chen, Chin-Tu — University of Chicago
- Study coordinator: Chen, Chin-Tu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.